Site-resolved assessment of targeted protein degradation

Ricardo Moreno-Ballesteros, Thomas Pembridge, Gaurav Beniwal, Satpal Virdee

Cell Chemical Biology

BPI technology enables multi-site assessment of targeted protein degradation
Effector sites are sensitised to a generic probe using genetic code expansion
Pharmacologically relevant outcomes are achieved without requiring specific ligands
BPI technology offers a powerful framework to explore induced proximity systematically

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