Our Approach
Inhibiting E3 ligases to stabilise proteins and treat disease
E3 ligases are a key part of the Ubiquitin Proteasome System (UPS) which is important in enabling cells to mark and target proteins that need to be broken down.
Degradation of critical proteins in disease
Cancer and neurodegeneration can hijack E3 ligase controlled processes and degrade critical proteins, enabling the disease to develop and spread.
Restoring health by stabilising proteins
Protein stabilisation seeks to maintain the levels of critical proteins and restore the body’s disease suppression processes, returning proteins to homeostasis.
Therapeutic benefit of inhibiting E3 ligases
The blocking of E3 ligase activity has the advantage of enabling protein stabilisation “at source”, preventing ubiquitin tagging which signposts proteins for degradation.
Protein stabilisation could be applicable to a wide range of indications, including oncology and neurology.
© Outrun Therapeutics
